Help me get out of town

Anyone got any thoughts on a place for me to go for two days in October that fulfills these requirements:

1. I don't have to drive more than 4 hours.
2. There is something artsy to do.
3. There is hiking or walking or biking options.
4. If all else fails on any of the above, the place I'm going has a couple of good restaurants or indoor entertainment (get your minds of of the gutter).

Thoughts? Shoot them my way.